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Polymorphism and crystal transformation of penicillin sulfoxide
Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG
《化学科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 442-447 doi: 10.1007/s11705-011-1140-x
关键词: penicillin sulfoxide crystallization polymorphism crystal transformation Raman spectroscopy
Immobilization of penicillin G acylase onto amino-modified silica hydrogel
Weibing Dong, Huining HE, Junbo Gong, Victor C. YANG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 87-90 doi: 10.1007/s11705-009-0298-y
关键词: gravimetric amino-modified efficient Amino-modified amoxicillin
Methyl acetate–methanol mixture separation by extractive distillation: Economic aspects
Elena Graczová, Branislav Šulgan, Samuel Barabas, Pavol Steltenpohl
《化学科学与工程前沿(英文)》 2018年 第12卷 第4期 页码 670-682 doi: 10.1007/s11705-018-1769-9
Methyl acetate is considered low toxicity volatile solvent produced either as a by-product during methanol carbonylation or via acetic acid esterification with methanol. In both cases, pure methyl acetate has to be isolated from the reaction mixture. Simulation of methyl acetate separation from its mixture with methanol by extraction distillation was carried out in ASPEN+ software. In total three case studies were assumed using two different extraction solvents and two solvent regeneration strategies. In case A, novel extraction solvent 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ionic liquid, was considered. Raw material separation was achieved in an extraction distillation column while the solvent regeneration was accomplished in a second distillation column in this case. In case study B, the same extraction solvent was used; however, its regeneration was carried out in a single-effect evaporator. Dimethyl sulfoxide was the second extraction solvent selected. Its use in methyl acetate-methanol separation is presented in case study C. As high purity of dimethyl sulfoxide was required for the methyl acetate-methanol azeotrope breaking, its regeneration was carried out in the second distillation column only. To simulate the ternary methyl acetate–methanol–extraction solvent mixtures separation, vapor–liquid equilibrium was predicted based on the NRTL equation. Further, unknown properties of the considered ionic liquid and variation of these properties with temperature were predicted and introduced into the ASPEN+ components properties database. Based on these data, optimum operation parameters of the respective separation equipment were established. In all case studies, the same condition had to be fulfilled, namely minimum methyl acetate content in the distillate from the extraction distillation column of 99.5mol-%. Results of simulations using the respective optimum operation parameters were employed in the economic evaluation of the three separation unit designs studied. It was found that the least energy-demanding design corresponds to the case study B in terms of both capital as well as operation expenses.
关键词: methyl acetate 1-ethyl-3-methylimidazolium trifluoromethanesulfonate extraction distillation dimethyl sulfoxide economic evaluation
标题 作者 时间 类型 操作
Polymorphism and crystal transformation of penicillin sulfoxide
Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG
期刊论文
Immobilization of penicillin G acylase onto amino-modified silica hydrogel
Weibing Dong, Huining HE, Junbo Gong, Victor C. YANG,
期刊论文